Kidney Disease for People Living with HIV in Sub-Saharan Africa; A Systematic Review
Abstract
People living with HIV have been known to have a higher risk and threat of kidney disease. Globally, the prevalence of kidney disease for PLWH is postulated to be 6.4%. This prevalence is different for many different parts of the world, with 7.9% in Africa, 7.1% in North America, 5.7% in Asia and 3.7% in Europe. This systematic review set out to review and collect evidence from literature source and to provide a summary about factors influencing kidney disease for PLWH in Africa. We hypothesized that TDF containing ART is significantly associated with kidney disease. A systematic review and search of data was performed and all articles included were English articles from the following electronic databases: PubMed, Google Scholar and Embase. We carried out the selection of titles in three distinct phases: titles alone, abstracts, and then full text articles. 7 papers were included. While TDF was included in the ART regimens in all the studies, there was wide variation in ART combinations and concurrent medications and durations thereof. All studies except one included only adult patients of both men and women. Majority of the studies highlighted kidney disease and mostly these were hospital-based data. the findings establish a significant association between kidney disease and TDF use, but in terms of the clinical significance and weighting the risks against the benefits, we cannot discourage the continual use of the drug.
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