Factors Associated with Short Term Outcomes of Hypospadias Repair at the University Teaching Hospitals-Lusaka, Zambia
Keywords:
Hypospadias, Short Term Outcomes, Complications, Complication Rate, Urethrocutaneous Fistula, Glanular Dehiscence, Persistent Chordee, Penile Torsion
Abstract
The study aimed to establish whether age at the time of surgery, glans size, urethral plate width, suture material, urethral catheter blockage/dislodgement and haemoglobin level influence short term outcomes of hypospadias surgery at the University Teaching Hospitals (UTH), Lusaka Zambia. This was a consecutive (total enumerative) observational cohort study done at D-block and Clinic 7 at UTH Lusaka over nine months. A total of 41 patients were enrolled, and their demographic data, haemoglobin, maximum glans width size and urethral plate size before creating glans wing or midline plate incision were noted and measured. Logistic regression assessed urethroplasty complications on urethral plate size, glans size, haemoglobin, suture material and catheter problems. The average age of participants was 34 months. Distal hypospadias was the most common type at 61%, while middle hypospadias was 27% and proximal hypospadias 12%. The complication rate was 34%. The most common complication seen was urethrocutaneous fistula at 53%. The other complications seen included 11.8% glanular dehiscence, 11.8% infections, 6% persistent chordee and 6% penile torsion. The risk factors for postoperative complications included the location of the urethral opening. The more proximal the site of the hypospadias, the higher the complication rate. Complications were strongly associated with haemoglobin levels of less than 11.5g/dl (p=0.001) and catheter blockage or dislodgment (p=0.008). There was no association of complications with Socioeconomic status, age at the time of repair, glans width size or suture material. Contrary to the finding of many authors, a wider urethral plate in this study was associated with a higher complication rate.References
1. Abdelrahman MYH, Abdeljaleel IA, Mohamed E, Bagadi A-TO, Khair OEM. Hypospadias in Sudan, clinical and surgical review. Afr J Paediatr Surg AJPS. 2011 Dec;8(3):269–71.
2. Ashcraft KW, Holcomb GW, Murphy JP, Ostlie DJ, editors. Ashcraft’s pediatric surgery. Sixth edition. London ; New York: Saunders/Elsevier; 2014. 1165
3. Bhat, A., Mandal, A.K., 2008. Acute postoperative complications of hypospadias repair. Indian J. Urol. IJU J. Urol. Soc. India 24, 241–248.
4. Aisuodionoe-Shadrach OI, Atim T, Eniola BS, Ohemu AA. Hypospadias repair and outcome in Abuja, Nigeria: A 5-year single-centre experience. Afr J Paediatr Surg AJPS. 2015 Mar;12(1):41–4.
5. Lopes, J.F., Schned, A., Ellsworth, P.I., Cendron, M., 2001. Histological analysis of urethral healing after tubularized incised plate urethroplasty. J. Urol. 166, 1014–1017.
6. Wu, V.K., Poenaru, D., Poley, M.J., 2013. Burden of Surgical Congenital Anomalies in Kenya: A Population-Based Study. J. Trop. Pediatr. 59, 195–202. https://doi.org/10.1093/tropej/fmt001
7. Coran, A.G., Adzick, N.S., ScienceDirect (Service en ligne), 2012. Pediatric surgery. Elsevier Mosby, Philadelphia, Pa.
8. Olajide O, Sowande AO, Salako AA, Olajide FO, Adejuyigbe O. challenges of surgical repair in Ile-Ife, Nigeria. AJU (African Journal of Urology). 2009 No;15:96–102.
9. Aho MO, Koivisto A-M, Juhani Tammela TL, Auvinen A-P. Geographical differences in the prevalence of hypospadias in Finland. Environ Res. 2003 Jun 1;92(2):118–23.
10. Raftery, A.T., 2008. Applied basic science for basic surgical training. Churchill Livingstone, Edinburgh; New York.
11. Sadler, T.W., Langman, J., 2012. Langman’s medical embryology, 12th ed. ed. Wolters Kluwer Health/Lippincott Williams & Wilkins, Philadelphia
12. Springer, A., van den Heijkant, M., Baumann, S., 2016. Worldwide prevalence of hypospadias. J. Pediatr. Urol. 12, 152.e1–7. https://doi.org/10.1016/j.jpurol.2015.12.002
13. Wilkinson DJ, Green PA, Beglinger S, Myers J, Hudson R, Edgar D, et al. Hypospadias surgery in England: Higher volume centres have lower complication rates. J Pediatr Urol. 2017 Oct;13(5):481.e1-481.e6.
14. Snodgrass W, Bush N. Recent advances in understanding/management of hypospadias. F1000prime Rep. 2014;6:101.
15. Osifo OD, Mene AO. Hypospadias repair in a resource-poor region: coping with the challenges in 5 years. J Pediatr Urol. 2010 Feb;6(1):60–5.
16. Hayashi Y, Kojima Y. Current concepts in hypospadias surgery. Int J Urol. 2008 Aug 1;15(8):651–64.
17. Mosharafa, A.A., Agbo-Panzo, D., Priso, R., Aubry, E., Besson, R., 2009. [Repair of hypospadias: the effect of urethral plate configuration on the outcome of DuplaySnodgrass repair]. Progres En Urol. J. Assoc. Francaise Urol. Soc. Francaise Urol. 19, 507–510. https://doi.org/10.1016/j.purol.2009.02.013
18. Hardwicke J, Jones E, Wilson-Jones N. Optimization of silicone urinary catheters for hypospadias repair. J Pediatr Urol. 2010 Aug;6(4):385–8.
19. Demirbilek S, Atayurt HF. One-stage hypospadias repair with a stent or suprapubic diversion: which is better? J Pediatr Surg. 1997 Dec;32(12):1711–2.
20. McCormack M, Homsy Y, Laberge Y. “No stent, no diversion” Mathieu hypospadias repair. Can J Surg J Can Chir. 1993 Apr;36(2):152–4.
21. De Badiola F, Anderson K, Gonzalez R. Hypospadias repair in an outpatient setting without proximal urinary diversion: experience with 113 urethroplasties. J Pediatr Surg. 1991 Apr;26(4):461–4; discussion 464-465.
22. Nguyen MT, Snodgrass WT, Zaontz MR. Effect of urethral plate characteristics on tabularised incised plate urethroplasty. J Urol. 2004 Mar;171(3):1260–2; discussion 1262.
23. Sarhan O, Saad M, Helmy T, Hafez A. Effect of suturing technique and urethral plate characteristics on complication rate following hypospadias repair: a prospective randomised study. J Urol. 2009 Aug;182(2):682–5; discussion 685-686.
24. Faasse MA, Johnson EK, Bowen DK, Lindgren BW, Maizels M, Marcus CR, et al. Is glans penis width a risk factor for complications after hypospadias repair? J Pediatr Urol. 2016 Aug; 12(4):202.e1-5.
2. Ashcraft KW, Holcomb GW, Murphy JP, Ostlie DJ, editors. Ashcraft’s pediatric surgery. Sixth edition. London ; New York: Saunders/Elsevier; 2014. 1165
3. Bhat, A., Mandal, A.K., 2008. Acute postoperative complications of hypospadias repair. Indian J. Urol. IJU J. Urol. Soc. India 24, 241–248.
4. Aisuodionoe-Shadrach OI, Atim T, Eniola BS, Ohemu AA. Hypospadias repair and outcome in Abuja, Nigeria: A 5-year single-centre experience. Afr J Paediatr Surg AJPS. 2015 Mar;12(1):41–4.
5. Lopes, J.F., Schned, A., Ellsworth, P.I., Cendron, M., 2001. Histological analysis of urethral healing after tubularized incised plate urethroplasty. J. Urol. 166, 1014–1017.
6. Wu, V.K., Poenaru, D., Poley, M.J., 2013. Burden of Surgical Congenital Anomalies in Kenya: A Population-Based Study. J. Trop. Pediatr. 59, 195–202. https://doi.org/10.1093/tropej/fmt001
7. Coran, A.G., Adzick, N.S., ScienceDirect (Service en ligne), 2012. Pediatric surgery. Elsevier Mosby, Philadelphia, Pa.
8. Olajide O, Sowande AO, Salako AA, Olajide FO, Adejuyigbe O. challenges of surgical repair in Ile-Ife, Nigeria. AJU (African Journal of Urology). 2009 No;15:96–102.
9. Aho MO, Koivisto A-M, Juhani Tammela TL, Auvinen A-P. Geographical differences in the prevalence of hypospadias in Finland. Environ Res. 2003 Jun 1;92(2):118–23.
10. Raftery, A.T., 2008. Applied basic science for basic surgical training. Churchill Livingstone, Edinburgh; New York.
11. Sadler, T.W., Langman, J., 2012. Langman’s medical embryology, 12th ed. ed. Wolters Kluwer Health/Lippincott Williams & Wilkins, Philadelphia
12. Springer, A., van den Heijkant, M., Baumann, S., 2016. Worldwide prevalence of hypospadias. J. Pediatr. Urol. 12, 152.e1–7. https://doi.org/10.1016/j.jpurol.2015.12.002
13. Wilkinson DJ, Green PA, Beglinger S, Myers J, Hudson R, Edgar D, et al. Hypospadias surgery in England: Higher volume centres have lower complication rates. J Pediatr Urol. 2017 Oct;13(5):481.e1-481.e6.
14. Snodgrass W, Bush N. Recent advances in understanding/management of hypospadias. F1000prime Rep. 2014;6:101.
15. Osifo OD, Mene AO. Hypospadias repair in a resource-poor region: coping with the challenges in 5 years. J Pediatr Urol. 2010 Feb;6(1):60–5.
16. Hayashi Y, Kojima Y. Current concepts in hypospadias surgery. Int J Urol. 2008 Aug 1;15(8):651–64.
17. Mosharafa, A.A., Agbo-Panzo, D., Priso, R., Aubry, E., Besson, R., 2009. [Repair of hypospadias: the effect of urethral plate configuration on the outcome of DuplaySnodgrass repair]. Progres En Urol. J. Assoc. Francaise Urol. Soc. Francaise Urol. 19, 507–510. https://doi.org/10.1016/j.purol.2009.02.013
18. Hardwicke J, Jones E, Wilson-Jones N. Optimization of silicone urinary catheters for hypospadias repair. J Pediatr Urol. 2010 Aug;6(4):385–8.
19. Demirbilek S, Atayurt HF. One-stage hypospadias repair with a stent or suprapubic diversion: which is better? J Pediatr Surg. 1997 Dec;32(12):1711–2.
20. McCormack M, Homsy Y, Laberge Y. “No stent, no diversion” Mathieu hypospadias repair. Can J Surg J Can Chir. 1993 Apr;36(2):152–4.
21. De Badiola F, Anderson K, Gonzalez R. Hypospadias repair in an outpatient setting without proximal urinary diversion: experience with 113 urethroplasties. J Pediatr Surg. 1991 Apr;26(4):461–4; discussion 464-465.
22. Nguyen MT, Snodgrass WT, Zaontz MR. Effect of urethral plate characteristics on tabularised incised plate urethroplasty. J Urol. 2004 Mar;171(3):1260–2; discussion 1262.
23. Sarhan O, Saad M, Helmy T, Hafez A. Effect of suturing technique and urethral plate characteristics on complication rate following hypospadias repair: a prospective randomised study. J Urol. 2009 Aug;182(2):682–5; discussion 685-686.
24. Faasse MA, Johnson EK, Bowen DK, Lindgren BW, Maizels M, Marcus CR, et al. Is glans penis width a risk factor for complications after hypospadias repair? J Pediatr Urol. 2016 Aug; 12(4):202.e1-5.
Published
2021-12-16
How to Cite
1.
Kalota S, Spasojevic N, Bvulani B. Factors Associated with Short Term Outcomes of Hypospadias Repair at the University Teaching Hospitals-Lusaka, Zambia. Journal of Agricultural and Biomedical Sciences [Internet]. 16Dec.2021 [cited 21Nov.2024];5(2). Available from: https://vet.unza.zm/index.php/JABS/article/view/688
Section
Biomedical Sciences
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